Comparative transcriptomic analysis of Tibetan Gynaephora to explore the genetic basis of insect adaptation to divergent altitude environments

doi:10.1038/s41598-017-17051-4

	Comparative transcriptomic analysis of Tibetan Gynaephora to explore the genetic basis of insect adaptation to divergent altitude environments
	Zhang, QL (Zhang, Qi-Lin); Zhang, L (Zhang, Li); Yang, XZ (Yang, Xing-Zhuo); Wang, XT (Wang, Xiao-Tong); Li, XP (Li, Xiao-Peng); Wang, J (Wang, Juan); Chen, JY (陈均远); Yuan, ML (Yuan, Ming-Long)
	2017
发表期刊	Scientific Reports
ISSN	2045-2322
卷号	7 页码:文献号：16972
摘要	Adaptation of insects to different altitudes remain largely unknown, especially those endemic to the Tibetan Plateau (TP). Here, we generated the transcriptomes of Gynaephora menyuanensis and G. alpherakii, inhabiting different high altitudes on the TP, and used these and the previously available transcriptomic and genomic sequences from low-altitude insects to explore potential genetic basis for divergent high-altitude adaptation in Gynaephora. An analysis of 5,869 orthologous genes among Gynaephora and other three low-altitude insects uncovered that fast-evolving genes and positively selected genes (PSGs) in the two Gynaephora species were enriched in energy metabolism and hypoxia response categories (e.g. mitochondrion, oxidation-reduction process, and response to oxidative stress). Particularly, mTOR signaling pathway involving hypoxia was enriched by PSGs, indicating this well-known pathway in mammal hypoxia adaptation may be an important signaling system in Gynaephora. Furthermore, some PSGs were associated with response to hypoxia (e.g. cytochrome proteins), cold (e.g. dehydrogenase) and DNA repair (e.g. DNA repair proteins). Interestingly, several insect-specific genes that were associated with exoskeleton and cuticle development (e.g. chitinase and ecdysteroids) had experienced positive selection, suggesting the specific adaptive mechanisms in insects. This study is favourable for understanding the adaptive evolution of Gynaephora and even TP insects to divergent altitudes.
DOI	10.1038/s41598-017-17051-4
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000417051000022
出版者	NATURE PUBLISHING GROUP
文献类型	期刊论文
条目标识符	http://ir.nigpas.ac.cn/handle/332004/13902
专题	中国科学院南京地质古生物研究所其他
通讯作者	Chen, JY (陈均远)
推荐引用方式 GB/T 7714	Zhang, QL ,Zhang, L ,Yang, XZ ,et al. Comparative transcriptomic analysis of Tibetan Gynaephora to explore the genetic basis of insect adaptation to divergent altitude environments[J]. Scientific Reports,2017,7:文献号：16972.
APA	Zhang, QL .,Zhang, L .,Yang, XZ .,Wang, XT .,Li, XP .,...&Yuan, ML .(2017).Comparative transcriptomic analysis of Tibetan Gynaephora to explore the genetic basis of insect adaptation to divergent altitude environments.Scientific Reports,7,文献号：16972.
MLA	Zhang, QL ,et al."Comparative transcriptomic analysis of Tibetan Gynaephora to explore the genetic basis of insect adaptation to divergent altitude environments".Scientific Reports 7(2017):文献号：16972.