NIGPAS OpenIR
Evolution of the Cholesterol Biosynthesis Pathway in Animals
Zhang, Tingting1,2,3; Yuan, Dongwei1,3,4; Xie, Jun5; Lei, Yongxing4,6; Li, Jianguo7; Fang, Gangqi3,4; Tian, Ling8; Liu, Jiacheng4,9; Cui, Yingying1; Zhang, Min2
2019-11-01
发表期刊MOLECULAR BIOLOGY AND EVOLUTION
ISSN0737-4038
卷号36期号:11页码:2548-2556
摘要

Cholesterol plays essential roles in animal development and disease progression. Here, we characterize the evolutionary pattern of the canonical cholesterol biosynthesis pathway (CBP) in the animal kingdom using both genome-wide analyses and functional experiments. CBP genes in the basal metazoans were inherited from their last common eukaryotic ancestor and evolutionarily conserved for cholesterol biosynthesis. The genomes of both the basal metazoans and deuterostomes retain almost the full set of CBP genes, while Cnidaria and many protostomes have independently experienced multiple massive losses of CBP genes that might be due to the geologic events during the Ediacaran period, such as the appearance of an exogenous sterol supply and the frequent perturbation of ocean oxygenation. Meanwhile, the indispensable utilization processes of cholesterol potentially strengthened the maintenance of the complete set of CBP genes in vertebrates. These results strengthen both biotic and abiotic roles in the macroevolution of a biosynthesis pathway in animals.

关键词cholesterol biosynthesis pathway gene loss Ediacaran period macroevolution
DOI10.1093/molbev/msz167
语种英语
关键词[WOS]SQUALENE SYNTHASE ; STEROL SYNTHESIS ; TRYPANOSOMA-CRUZI ; LANOSTEROL ; PHYLOGENIES ; FOSSILS ; CLONING ; ORIGIN ; GENOME ; RAFTS
资助项目National Science Foundation of China[31620103917] ; National Science Foundation of China[31572325] ; National Science Foundation of China[31501905] ; National Science Foundation of China[31522053] ; Chinese Academy of Sciences[XDB13030700] ; Chinese Academy of Sciences[QYZDB-SSW-SMC029] ; Chinese Academy of Sciences[XDB18000000] ; Chinese Academy of Sciences[XDB27040205] ; Chinese Academy of Sciences[153D31KYSB20160065] ; National Key Research and Development Program of China[2016YFD0101900] ; Postdoctoral Science Foundation of China[2016M591722]
WOS研究方向Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS类目Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS记录号WOS:000504091200013
项目资助者National Science Foundation of China ; Chinese Academy of Sciences ; National Key Research and Development Program of China ; Postdoctoral Science Foundation of China
出版者OXFORD UNIV PRESS
文献类型期刊论文
条目标识符http://ir.nigpas.ac.cn/handle/332004/29732
专题中国科学院南京地质古生物研究所
通讯作者Zhan, Shuai; Li, Sheng
作者单位1.South China Normal Univ, Inst Insect Sci & Technol, Sch Life Sci, Guangdong Prov Key Lab Insect Dev Biol & Appl Tec, Guangzhou, Guangdong, Peoples R China
2.Shanxi Univ, Res Inst Appl Biol, Taiyuan, Shanxi, Peoples R China
3.Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, CAS Key Lab Insect Dev & Evolutionary Biol, Inst Plant Physiol & Ecol, Shanghai, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Fudan Univ, Inst Genet, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China
6.Chinese Acad Sci, Inst Plant Physiol & Ecol, Key Lab Synthet Biol, Shanghai, Peoples R China
7.Shanxi Univ, Inst Biomed Sci, Taiyuan, Shanxi, Peoples R China
8.South China Agr Univ, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangdong Prov Sericulture & Mulberry Engn Res Ct, Coll Anim Sci, Guangzhou, Guangdong, Peoples R China
9.Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Innovat Ctr Cell Signaling Network, State Key Lab Mol Biol,CAS Ctr Excellence Mol Cel, Shanghai, Peoples R China
10.Chinese Acad Sci, Nanjing Inst Geol & Palaeontol, State Key Lab Paleobiol & Stratig, Nanjing, Jiangsu, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Tingting,Yuan, Dongwei,Xie, Jun,et al. Evolution of the Cholesterol Biosynthesis Pathway in Animals[J]. MOLECULAR BIOLOGY AND EVOLUTION,2019,36(11):2548-2556.
APA Zhang, Tingting.,Yuan, Dongwei.,Xie, Jun.,Lei, Yongxing.,Li, Jianguo.,...&Li, Sheng.(2019).Evolution of the Cholesterol Biosynthesis Pathway in Animals.MOLECULAR BIOLOGY AND EVOLUTION,36(11),2548-2556.
MLA Zhang, Tingting,et al."Evolution of the Cholesterol Biosynthesis Pathway in Animals".MOLECULAR BIOLOGY AND EVOLUTION 36.11(2019):2548-2556.
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