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Genome-wide comparison of the protein-coding repertoire reveals fast evolution of immune-related genes in cephalochordates and Osteichthyes superclass
Zhang, Qi-Lin1,2; Xu, Bin1; Wang, Xiu-Qiang1,2; Yuan, Ming-Long3; Chen, Jun-Yuan (陈均远)1,2
2018-01-02
Source PublicationONCOTARGET
ISSN1949-2553
Volume9Issue:1Pages:83-95
Abstract

Amphioxus is used to investigate the origin and evolution of vertebrates. To better understand the characteristics of genome evolution from cephalochordates to Osteichthyes, we conducted a genome-wide pairwise comparison of proteincoding genes within amphioxus (a comparable group) and parallel analyses within Osteichthyes (two comparable groups). A batch of fast-evolving genes in each comparable group was identified. Of these genes, the most fast-evolving genes (top 20) were scrutinized, most of which were involved in immune system. An analysis of the fast-evolving genes showed that they were enriched into gene ontology (GO) terms and pathways primarily involved in immune-related functions. Similarly, this phenomenon was detected within Osteichthyes, and more well-known and abundant GO terms and pathways involving innate immunity were found in Osteichthyes than in cephalochordates. Next, we measured the expression responses of four genes belonging to metabolism or energy production-related pathways to lipopolysaccharide challenge in the muscle, intestine or skin of B. belcheri; three of these genes (HMGCL, CYBS and MDH2) showed innate immune responses. Additionally, some genes involved in adaptive immunity showed fast evolution in Osteichthyes, such as those involving "intestinal immune network for IgA production" or "T-cell receptor signaling pathway". In this study, the fast evolution of immune-related genes in amphioxus and Osteichthyes was determined, providing insights into the evolution of immunerelated genes in chordates.

KeywordCephalochordates Osteichthyes Superclass Immune-related Genes Fast Evolution Protein-coding Genes Immunology
DOI10.18632/oncotarget.22749
Indexed BySCI
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000419615500008
PublisherIMPACT JOURNALS LLC
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.nigpas.ac.cn/handle/332004/22706
Collection中国科学院南京地质古生物研究所
其他
Affiliation1.Chinese Acad Sci, LPS Nanjing Inst Geol & Palaeontol, Nanjing, Jiangsu, Peoples R China;
2.Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing, Jiangsu, Peoples R China;
3.Lanzhou Univ, Coll Pastoral Agr Sci & Technol, State Key Lab Grassland Agro Ecosyst, Lanzhou, Gansu, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Qi-Lin,Xu, Bin,Wang, Xiu-Qiang,et al. Genome-wide comparison of the protein-coding repertoire reveals fast evolution of immune-related genes in cephalochordates and Osteichthyes superclass[J]. ONCOTARGET,2018,9(1):83-95.
APA Zhang, Qi-Lin,Xu, Bin,Wang, Xiu-Qiang,Yuan, Ming-Long,&Chen, Jun-Yuan .(2018).Genome-wide comparison of the protein-coding repertoire reveals fast evolution of immune-related genes in cephalochordates and Osteichthyes superclass.ONCOTARGET,9(1),83-95.
MLA Zhang, Qi-Lin,et al."Genome-wide comparison of the protein-coding repertoire reveals fast evolution of immune-related genes in cephalochordates and Osteichthyes superclass".ONCOTARGET 9.1(2018):83-95.
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