KMS Nanjing Institute of Geology and Palaeonotology,CAS
Genome-wide comparison of the protein-coding repertoire reveals fast evolution of immune-related genes in cephalochordates and Osteichthyes superclass | |
Zhang, Qi-Lin1,2; Xu, Bin1; Wang, Xiu-Qiang1,2; Yuan, Ming-Long3; Chen, Jun-Yuan (陈均远)1,2 | |
2018-01-02 | |
发表期刊 | ONCOTARGET |
ISSN | 1949-2553 |
卷号 | 9期号:1页码:83-95 |
摘要 | Amphioxus is used to investigate the origin and evolution of vertebrates. To better understand the characteristics of genome evolution from cephalochordates to Osteichthyes, we conducted a genome-wide pairwise comparison of proteincoding genes within amphioxus (a comparable group) and parallel analyses within Osteichthyes (two comparable groups). A batch of fast-evolving genes in each comparable group was identified. Of these genes, the most fast-evolving genes (top 20) were scrutinized, most of which were involved in immune system. An analysis of the fast-evolving genes showed that they were enriched into gene ontology (GO) terms and pathways primarily involved in immune-related functions. Similarly, this phenomenon was detected within Osteichthyes, and more well-known and abundant GO terms and pathways involving innate immunity were found in Osteichthyes than in cephalochordates. Next, we measured the expression responses of four genes belonging to metabolism or energy production-related pathways to lipopolysaccharide challenge in the muscle, intestine or skin of B. belcheri; three of these genes (HMGCL, CYBS and MDH2) showed innate immune responses. Additionally, some genes involved in adaptive immunity showed fast evolution in Osteichthyes, such as those involving "intestinal immune network for IgA production" or "T-cell receptor signaling pathway". In this study, the fast evolution of immune-related genes in amphioxus and Osteichthyes was determined, providing insights into the evolution of immunerelated genes in chordates. |
关键词 | Cephalochordates Osteichthyes Superclass Immune-related Genes Fast Evolution Protein-coding Genes Immunology |
DOI | 10.18632/oncotarget.22749 |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Oncology ; Cell Biology |
WOS类目 | Oncology ; Cell Biology |
WOS记录号 | WOS:000419615500008 |
出版者 | IMPACT JOURNALS LLC |
文献类型 | 期刊论文 |
条目标识符 | http://ir.nigpas.ac.cn/handle/332004/22706 |
专题 | 中国科学院南京地质古生物研究所 其他 |
作者单位 | 1.Chinese Acad Sci, LPS Nanjing Inst Geol & Palaeontol, Nanjing, Jiangsu, Peoples R China; 2.Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing, Jiangsu, Peoples R China; 3.Lanzhou Univ, Coll Pastoral Agr Sci & Technol, State Key Lab Grassland Agro Ecosyst, Lanzhou, Gansu, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Qi-Lin,Xu, Bin,Wang, Xiu-Qiang,et al. Genome-wide comparison of the protein-coding repertoire reveals fast evolution of immune-related genes in cephalochordates and Osteichthyes superclass[J]. ONCOTARGET,2018,9(1):83-95. |
APA | Zhang, Qi-Lin,Xu, Bin,Wang, Xiu-Qiang,Yuan, Ming-Long,&Chen, Jun-Yuan .(2018).Genome-wide comparison of the protein-coding repertoire reveals fast evolution of immune-related genes in cephalochordates and Osteichthyes superclass.ONCOTARGET,9(1),83-95. |
MLA | Zhang, Qi-Lin,et al."Genome-wide comparison of the protein-coding repertoire reveals fast evolution of immune-related genes in cephalochordates and Osteichthyes superclass".ONCOTARGET 9.1(2018):83-95. |
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